Publicaciones Internacionales de Mayor relevancia generadas en el PDI desde su fundacion




  • Scand J Rheumatol. Nov-Dec;35(6):435-40.Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis.
  • Immunobiology 2006; 211(1-2): 75-84. Could single nucleotide polymorphisms (SNPs) affecting to the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
  • Immunobiology. 211:11-27.Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and cellular immune responses in mice.


  • Journal of Rheumatology; 32: 2116-2124. Anti- Tumor Necrosis Factor-α therapy augments Dipeptidyl Peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis.
  • Biological Research; 38: 7-12.Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy.


  • J Immunol. Aug 1;173(3):1731-7.  A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells.
  • European Cytokine Network; 15 (4): 364-370. The –308 polymorphism in the promoter region of tumor necrosis factor-alpha (TNFα) gene and ex vivo lipopolysaccharide-induced TNFα expression in patients with aggressive periodontitis.


  • Rheumatology (Oxford) 2003; 42: 308-313.The –308 polymorphism in the tumor necrosis factor gene promoter region and ex - vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in chilean patients with rheumatoid arthritis.



  • Biological Research 2001; 34: 237-241.Genetic polymorphism at position –308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population.


  • Acta Tropica 2000; 75: 291-300. Development of an immunoenzymatic  assay   for the detection  of   human antibodies against Trypanosoma cruzi calreticulin, an immunodominant antigen.



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